trinucleotide repeat definition

Generally, the larger the expansion the more likely they are to cause disease or increase the severity of disease.
When the cause of a disease can be traced to having too many copies of a certain nucleotide triplet in the DNA, the disease is said to be a trinucleotide repeat disorder. The English word games are: Generally, the larger the expansion the more likely they are to cause disease or increase the severity of disease. This property results in the characteristic of anticipation seen in trinucleotide repeat disorders. Letters must be adjacent and longer words score better. Add new content to your site from Sensagent by XML. Supplement The trinucleotide repeats expand in successive generations and their effect depends on … [4], News Release, Weizmann Institute of Science, "Scientists at the Weizmann Institute, using computer simulations, have provided an explanation as to why certain genetic diseases caused by repeats in the code are “genetic time-bombs” whose onset and progression can be accurately predicted," November 21, 2007, at, "DNA slip-outs cause RNA polymerase II arrest in vitro: potential implications for genetic instability", "New insights into repeat instability: Role of RNA•DNA hybrids", "Repeat instability during DNA repair: Insights from model systems", http://80.70.129.162/site/en/weizman.asp?pi=371&doc_id=5042, https://en.wikipedia.org/w/index.php?title=Trinucleotide_repeat_expansion&oldid=937532949, Creative Commons Attribution-ShareAlike License, This page was last edited on 25 January 2020, at 16:56. Contact Us Some CHROMOSOME FRAGILE SITES are composed of sequences where trinucleotide repeat expansion occurs. [2] and similar ideas turned to be a fashion ongoing issue of the mechanism studies ever since [3] [4]. [4], The number of trinucleotide repeats appears to predict the progression, severity, and age of onset of Huntington's disease and similar trinucleotide repeat disorders.

Richards RI, Sutherland GR (1997).
[1] Triplet expansion is caused by slippage during DNA replication, also known as "copy choice" DNA replication. Boggle gives you 3 minutes to find as many words (3 letters or more) as you can in a grid of 16 letters. Due to the repetitive nature of the DNA sequence in these regions, 'loop out' structures may form during DNA replication while maintaining complementary base pairing between the parent strand and daughter strand being synthesized. Eco, Cookies help us deliver our services. Give contextual explanation and translation from your sites ! However, if the loop out structure is formed on the parent strand, a decrease in the number of repeats occurs. Salinas-Rios V, Belotserkovskii BP, Hanawalt PC (2011). The number of repeats can change as the gene is passed from parent to child. "Dynamic mutation: possible mechanisms and significance in human disease". …of deoxyribonucleic acid (DNA) called CAG trinucleotide repeats. English Encyclopedia is licensed by Wikipedia (GNU).

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